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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can cut down panobinostat concentrations by ~70% and lead to remedy failure.pentobarbital will lessen the level or influence of carvedilol by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Ch